Paul Brennan
Paul Brennan
University of Oxford
Professor of Medicinal Chemistry
Paul Brennan received his PhD in organic chemistry from UC Berkeley. Following post-doctoral research at Cambridge University, Paul spent eight years working in the pharmaceutical industry at Amgen and Pfizer. After leaving Pfizer in 2011, Paul joined the Structural Genomics Consortium at the University of Oxford and led the chemical probes discovery effort on epigenetic targets. After leaving the SGC in 2019, Paul was Head of Chemistry and then CSO of the Alzheimer’s Research UK Oxford Drug Discovery Institute where his research was focused on finding new treatments for dementia. Paul is currently Professor of Medicinal Chemistry and Director of the Centre for Medicines Discovery at the University of Oxford. Over the course of his career, Paul has worked on most major drug targets classes: kinases, GPCRs, ion-channels, metabolic enzymes, and epigenetic proteins. His current research is on target validation in neurodegeneration, oncology, virology, and rare diseases; and chemical probe discovery for E3 ligases and small GTPases.
